Patterns of axon diameter.   Details of individual nerve cells can differ considerably among species.   In these micrographs of axon bundles from the necks of several different flies, the diameters of individual nerve fibers (pale circles) vary markedly from species to species.   Such variation suggests wonderful flexibility for the genes controlling nerve cell structure.

Tabanidae / Syrphidae / Rhagioniidae / Bombyliidae

    Axon diameter is closely related to several functional properties including conduction velocity (or electrotonic decrement in passively conducting axons), synaptic divergence ratio, and current available for electrical transmission.  Larger axons should be faster and better able to activate numerous postsynaptic neurons.  But smaller axons may be more economical, with lower metabolic costs to support less-extensive axoplasm.  Thus large axons might be expected in pathways where speed, individual reliability, or extensive synaptic output have selective advantage, while small axons might be favored where such factors have less adaptive significance.  The most extreme examples of evolutionary specialization affecting individual axonal size are the phylogenetically diverse occurrences of giant fibers in startle-response pathways. Lauxaniiidae
    The cervical connective of flies encompasses several thousand axons whose cross-sectional areas can differ by more than three orders of magnitude.  A common pattern for axon organization is revealed by the spatial arrangement of identifiable axons and tracts.  These display a fair constancy of size and position which is apparent through bilateral symmetry within a species, and less precise but still recognizable similarities among different species.
    Most larger axons are concentrated in a dorsomedial tract, while smaller axons are located ventrally and laterally.  The relative sizes of dorsal-tract axons vary widely among species, so that the proportion of the connective devoted to the 10 largest axons ranges from less than 5% to more than 30%.  This proportion appears to be greatest among flies with exceptional flying skill such as asilids (robber flies), bombyliids (bee flies), and syrphids (hover flies).  One pair of "giant" dorsomedial axons (GF in the figure) is found in most but not all cyclorrhaphans (fruit flies, house flies, blow flies, and their kin).  One or two pairs of very large axons also occur ventrally in many species; occasionally these large ventral axons assume "giant" proportions.  Many flies possess a coherent ventromedial bundle of very small (less than 0.5Ám) axons.  The number of axons in this bundle is quite variable; no such tract is apparent in several species of diverse taxonomic affinities.
    These observations suggest that diversity in the dipteran ventral nervous system may provide an excellent opportunity to explore the genetic and developmental constraints which influence evolutionary differentiation of neuronal form, particularly axon diameter.

        SOCIETY FOR NEUROSCIENCE ABSTRACTS, 1985.

Also see: Comparative neurobiology    2006 essay   /  1997 essay

King home page

-----------

Comments and questions: dgking@siu.edu
Department of Zoology e-mail: zoology@zoology.siu.edu
Comments and questions related to web server: webmaster@science.siu.edu


SIUC / College of Science / Zoology / Faculty / David King
URL: http://www.zoology.siu.edu/king/flynecks.htm
Last updated: 1 December 2006 / dgk